Research & Development

Synthetic and Medicinal Chemistry

Zasya’s state-of-the-art Research and Development infrastructure positions the company as a leading global CRO/CDMO, catering to diverse needs in drug discovery and development. The facility is equipped with fully operational and modern laboratories designed to support cutting-edge research. Zasya provides dedicated labs for both drug discovery and process development, ensuring focused and streamlined operations.

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Synthetic and Medicinal Chemistry

At Zasya, we specialize in designing and synthesizing NCEs, including peptides, oligonucleotides, PROTACs, heterocycles to support drug discovery efforts.

Using advanced techniques, we work closely with clients to optimize molecules from discovery to lead optimization, ensuring the development of potent, selective candidates.

Our facilities are equipped to handle the synthesis of key intermediates and APIs in quantities needed for testing, ensuring high-quality production that meets regulatory standards.
At Zasya, our ADL combines advanced instrumentation like NMR, HRMS, LCMS, and HPLC with a dedicated team to deliver precise data for R&D programs.
We offer in house and outsourced analytical services, potent, selective candidates.

Synthetic and Medicinal Chemistry Expertise

Zasya excels in synthetic and medicinal chemistry, driven by a commitment to helping customers accelerate their programs to clinical stages. The team provides comprehensive chemistry support across all stages of discovery, from exploratory research, hit-to-lead, lead optimization, to candidate selection.

With a proven track record of solving complex synthesis challenges, Zasya has contributed to the discovery of multiple preclinical candidates. By combining scientific expertise with cutting-edge technology, Zasya delivers tailored solutions to meet its customers’ requirements.

Capabilities in Synthetic and Medicinal Chemistry

Route design

Custom synthesis

Parallel synthesis

Library design and synthesis

Complex Chemistry

Scientific Expertise

Peptides

PROTACs

Heterocycles

Carbohydrates

Aliphatic compounds

Nucleosides

Oligonucleotides and much more...

Zasya offers FTE, FFS, and risk-sharing models to adapt to the unique needs of its partners.

Chemical process R&D

Zasya offers Route Scouting Fir-for-purpose development (For NCEs) Process development (For NCEs, API intermediates and APIs) focusing on safe, cost effective and scalable chemical processes, optimizing reaction condition and enhancing yields, tailored to the customer requirements.

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Scientific Expertise

Our team utilizes leading computational tools and platforms, including

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Kilo Lab & Small-Scale Manufacturing

Zasya offers specialized kilo-lab and small-scale manufacturing services to support preclinical and clinical development. Our facilities are equipped to handle the synthesis of key intermediates and APIs in quantities needed for testing, ensuring high-quality production that meets regulatory standards.

Additional chemical process R&D capabilities

Preparation of APIs for non clinical safety studies

Optimization of reaction conditions

de-novo route design

Manufacturing

FTEs

FFS

Risk Sharing

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Analytical Sciences

At Zasya, our ADL combines advanced instrumentation like NMR, HRMS, LCMS, and HPLC with a dedicated team to deliver precise data for R&D programs.

We offer in house and outsourced analytical services, including impurity profiling, stability studies, and method development, and characterization.

With rapid turnaround times and a high quality, we provide reliable support for every stage of drug discovery and development.

Process Development and Scale-Up

Zasya’s process R&D expert scientists, consistently exceeds expectations even for the most challenging projects. The team collaborates closely with customers to conduct route scouting and optimize reaction conditions for scale-up under both non-GMP and GMP conditions.
Zasya’s kilo-scale laboratories are equipped to handle processes from hundreds of grams to hundreds of kilograms, ensuring rapid and scalable solutions. Key features include
  • Multiple Jacketed Glass Reactors (10L to 3KL)
  • Large-Scale Hydrogenation (80L & 1000L, non-GMP/GMP)
  • Wide Temperature Range (-78°C to 220°C)

Zasya’s expertise extends to c-GMP manufacturing of APIs, ensuring seamless production from grams to metric tons without requiring technology transfer. Whether for toxicological studies, clinical trials, or commercial supplies, Zasya delivers reliable results.

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Additional Capabilities

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Preparation of APIs for Non-Clinical Safety Studies

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Optimization of Reaction Conditions

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De-Novo Route Design

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Custom Synthesis of Reference Standards, Impurities, Metabolites, and Scaffolds

Zasya’s robust infrastructure and capabilities ensure the efficient delivery of high-quality solutions, reinforcing its reputation as a trusted partner for pharmaceutical innovation.