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Introduction: Targeted induced-proximity therapeutics have transformed drug discovery. PROTACs induce ubiquitin-mediated degradation of disease proteins, whereas RIPTACs selectively eliminate biomarker-positive cells by recruiting essential proteins to disease-specific proteins. Mechanistic Differences PROTACs vs RIPTACs: Figure-1: Mechanism of action- PROTACs vs RIPTACs Detailed Comparison- PROTACs vs RIPTACs: Parameter PROTACs RIPTACs Full Form Proteolysis Targeting Chimera Regulated Induced […]

Introduction: Fostemsavir is a first-in-class HIV-1 attachment inhibitor approved for heavily treatment-experienced adults with multidrug-resistant HIV-1 infection. It is an orally administered phosphonooxymethyl prodrug that is rapidly converted to the active metabolite, temsavir. Temsavir binds the conserved pocket on the HIV-1 envelope glycoprotein gp120 adjacent to the CD4-binding site, preventing viral attachment to CD4+ T […]