Custom Library Synthesis

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Custom Library Synthesis

Zasya Life Sciences’ library synthesis service deliver targeted arrays of drug-like compounds. We are well-versed in deploying various state-of-the-art instruments and techniques, routinely delivering focused chemical libraries ranging in synthetic and structural complexity.
The computational chemistry team works alongside medicinal chemists during the library design and enumeration process.

Synthetic Chemistry Expertise

Zasya excels in delivering solutions to complex synthetic challenges, enabling customers to accelerate their programs to clinical stages. Our expertise spans all aspects of synthetic and medicinal chemistry, supported by cutting-edge technology and extensive experience.

Key Areas of Expertise

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Heterocyclic Chemistry

Synthesis and decoration of C-, N-, O-, and S-containing heterocycles. Derivatization of fused-heterocyclic systems and saturated heterocycles with C-N, C-O, and C-P bonds

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Transition Metal-Mediated Reactions
Pd-, Cu-, Zn-, and Ni-mediated C-C, C-N, and C-O bond-forming reactions. Metal-mediated C-S, C-P, and C-B bond-forming reactions. C-H activation chemistry and carbonylation reactions. Ring-closing metathesis and click chemistry.
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Handling of Gaseous Reactions
Expertise in reactions involving gases like H₂, Cl₂, O₂, CO, CO₂, and SO₃. Ozonolysis reactions. Hydrogenation reactions.
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Novel and emerging modalities
Synthesis of Peptides, PROTACs, molecular glues, carbohydrates and Oligonucleotides
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Niche Fields of Interest
Photoredox and electro-organic reactions. Decarboxylative C-C bond-forming reactions.
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Handling of Sensitive Agents
Air-sensitive reagents like organolithiums, Grignard reagents, and organozinc.. Strong reducing reagents, including Pd-C, LAH, borane, and super-hydrides. Synthesis of azides and phosphoramidites.

Collaborative Models

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FTE (Full-Time Equivalent)

Dedicated teams focused on client-specific projects.

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FFS (Fee-for-Service)

Flexibility to handle one-off or specialized tasks.

Why Choose Zasya?

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Extensive Experience

over >100 collective of experience in library design and synthesis services across diverse industries, including pharmaceuticals, agrochemicals, and animal health
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Rapid Turnaround Time

Our streamlined workflow enables fast delivery of solutions to customers
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Diverse Chemistry Capabilities

We offer a wide range of synthetic technologies to deliver customized solutions
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Customized Workflow

Our ability to adapt and deliver solutions as per customer requirements in meeting project specific goals.
group of scientists working at the laboratory.

Purification and Characterization

Deliver compounds with right quality and quantity as per customer requirements.

Why Choose Zasya?

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Extensive Experience

over >100 collective of experience in library design and synthesis services across diverse industries, including pharmaceuticals, agrochemicals, and animal health

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2
Rapid Turnaround Time

Our streamlined workflow enables fast delivery of solutions to customers

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Customized Workflow

over >100 collective of experience in library design and synthesis services across diverse industries, including pharmaceuticals,

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Purification and Characterization

Deliver compounds with right quality and quantity as per customer requirements

group of scientists working at the laboratory.
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Diverse Chemistry Capabilities

We offer a wide range of synthetic technologies to deliver customized solutions

Our Capabilities

We are well-equipped to handle small focused library synthesis across various scales .Our infrastructure includes NMR, HRMS, HPLC, weighing balances and purification equipment.

We design libraries to meet specific therapeutic targets, using high-quality building blocks and scaffolds. Our process integrates solid-phase and solution-phase synthesis, ensuring flexibility and scalability.

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We employ a range of synthetic strategies, including:

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Purification & Characterization

We employ advanced purification techniques to ensure the highest quality of library compounds:

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Purification Systems

Combiflash, and Waters/Agilent systems for normal and reverse-phase purification, prep-purification

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Analytical Techniques

UPLC, HPLC, NMR, HRMS and LC-MS for accurate purity determination 

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Characterization
Each compound is analyzed for purity (>90%) using UPLC/LCMS
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Conclusion

Zasya Life Sciences is committed to delivering high-quality small custom libraries using a diverse range of synthetic technologies and purification techniques. Our experienced team, combined with required infrastructure, ensures rapid synthesis and high-purity compounds to accelerate your drug discovery processes.