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PROTAC Synthesis

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  • PROTAC Synthesis

PROTAC Synthesis and Services at Zasya Life Sciences

PROteolysis Targeting Chimeras (PROTACs) are innovative molecules that utilize the body’s ubiquitin-proteasome system to selectively degrade target proteins. Unlike traditional small molecule inhibitors, PROTACs can modulate “undruggable” targets, offering advantages such as enhanced potency, prolonged effects, and the ability to overcome resistance mechanisms. These properties make PROTACs a powerful tool in drug development
Our services are customizable to meet the specific needs of your project, from early discovery through to large-scale synthesis and screening.

Key Features of Our PROTAC Services

PROTAC Design and Synthesis

Incorporation of non-natural amino acids to enhance stability and bioactivity.

Customizable PROTAC

Zasya offers an extensive library of building blocks, E3 ligase ligands, and linkers, which can be rapidly assembled into PROTAC analogs. This accelerates drug discovery process by providing flexible options for the design and optimization of PROTACs

Linker Design and Optimization

Zasya develops diverse linkers -from flexible to rigid structures—customized for enhanced stability, target specificity, and biological activity, ensuring the optimal performance of the your PROTAC

Molecular Glues and Monovalent Degraders

Zasya also offers synthesis services for molecular glues and monovalent degraders, which represent alternative strategies for targeted protein degradation

Purification and Characterization

Zasya utilizes HPLC, prep-HPLC and SFC for purification and characterization. We also offer comprehensive analytical services to ensure the accurate characterization of the physicochemical properties and degradation activity of the synthesized molecules

Why Choose Zasya Life Sciences for PROTAC Services?

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Expertise in Targeted Protein Degradation
Our team has a deep understanding of PROTAC chemistry and drug discovery, providing innovative solutions for challenging target molecules. We bring extensive experience in the synthesis and optimization of PROTACs, molecular glues, and monovalent degraders
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Fully Customized Solutions
We offer fully tailored PROTAC design and synthesis services to meet your unique project needs. Whether you’re developing novel PROTACs, optimizing existing candidates, or exploring new degradation strategies, we will work closely with you to ensure your strategies are optimized for success
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End-to-End Support
From initial design to large-scale synthesis, we provide comprehensive support. Our solutions seamlessly integrate into your drug discovery pipeline.
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State-of-the-Art Facilities
Our laboratories are equipped with required technologies for the synthesis, purification, and analysis of complex PROTAC molecules. This ensures that all compounds meet stringent quality standards and are delivered on time, with the highest purity and reproducibility
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Accelerated Timelines
Thanks to our extensive library of building blocks, linkers, and E3 ligase ligands, we can rapidly generate and optimize PROTAC candidates, helping you accelerate your drug discovery process and reduce time-to-market

Conclusion

Zasya Life Sciences is committed to advancing the field of targeted protein degradation through our comprehensive PROTAC synthesis services. Whether you are developing novel PROTACs, optimizing existing candidates, or exploring molecular glue strategies, our team is equipped to support your drug discovery efforts.
With our custom solutions, state-of-the-art facilities, and deep expertise, we ensure your PROTAC-based drug discovery programs proceed efficiently and successfully.
Partner with Zasya Life Sciences to accelerate breakthrough therapies through targeted protein degradation.
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